Progeline Cream: Usage, Benefits, Side Effects, FAQs | AllBodyYoga (2023)

Human growth is an interesting mystery, the changes the human body undergoes as one age from an infant to an elderly person are genuinely fascinating.

The skin for example goes through a series of changes and then slowly begins to age when a person becomes elderly, the signs are visible as wrinkling and sagging skin begin to appear on a person’s body.Years before now, people might have accepted their fate and aged gracefully but these days with scientific research and development, there is a choice to slow down the aging process if you choose to and can afford the means involved.

The easiest and most popular way people get rid of skin aging changes is usually by undergoing plastic surgery. But that could be risky and complicated for some people, so the creation of anti-aging cream gives more people an opportunity to reverse or manage the skin sagging, wrinkling, dullness, and dehydration they experience during the aging process.

Progeline cream claims to be an impressive anti-aging cream according to the company that produces it, below is a complete guide that proves whether or not the anti-aging qualities of progeline are true.

Table of Contents

What Is Progeline Cream?

Progeline is an exceptional biomimetic peptide that is believed to have anti-aging properties. It was invented by Lucas Meyer Cosmetics and is derived from Elafin. It contains a mixture of glycerin, water, and dextran, and trifluoroacetyl tripeptide (1).

Glycerin is a natural compound that is present naturally in plant and animal matter, it is also a skin treatment ingredient that traps moisture when in contact with the skin. Dextran is a polysaccharide found in artificial tears, while trifluoroacetyl tripeptide-2 inhibits all the previously mentioned ingredients and acts as an anti-aging peptide.

What Is A Peptide?

Since Progeline identifies as a peptide, it is important to understand what it is and how it functions. A peptide is a source of protein where two or more amino acids are combined. Peptides contain amino acids that are especially good for the skin.

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The amino acids present in any peptide are usually fused as one by a chemical bond called a peptide bond. Peptides can contain as much as fifty amino acids in some cases depending on what they are being formulated to be used for.

Peptides are easier for the human body to absorb nutrients off (2) of because they are smaller than other sources of protein. They can penetrate the skin and intestines without the hassle and make contact with the bloodstream shortly.

According to their specific make-up of amino acids, peptides could both serve as a nutrient that improves the skin and possesses anti-aging properties or they could act as a nutrient that helps the body build its strength and muscle mass.

Progeline is a collagen peptide because of its anti-aging function in the body.

As a collagen peptide, it focuses on the human skin, with its main objective being to enhance overall skin health and slow down the aging process. Collagen peptides are known to remedy and reduce the appearance on wrinkles on the skin, it is also a vital protein supplement that may promote skin elasticity and hydration.

Progeline Cream: Usage, Benefits, Side Effects, FAQs | AllBodyYoga (1)

These peptides may also boost the generation of melanin, this is meant to protect the skin from the effects of exposure to sunlight or simply curb sun damage as melanin strengthens the skin remarkably.

Collagen peptides (3) are also known to be present in several anti-aging products that are said to lower the appearance of wrinkles, aid in skin firming, and encourage increased blood flow. Collagen peptides may also serve as a remedy for preventing age-induced bone loss.

What Are The Benefits Of Progeline Cream For Skin?

Earlier identified as a collagen peptide, Progeline is known especially for being the body’s defense system against all forms of aging. As the skin naturally weakens, progeline is meant to serve as a strengthener that improves the overall appearance of the skin, retaining its finest qualities and rejecting the changes that are accompanied by the aging process.

However, are these claims true? It’s important that we determine that based on research and user experiences. Highlighted below are the benefits of Progeline creams to the skin;

1. Progeline Cream May Reduce Signs Of Aging In People

Reports have proven that after application, progeline cream does not smoothen wrinkles upon application, but since it is still being tested, people would like to believe that as a long term effect it and constant application it would eventually result in the smoothing of wrinkles in its bid to curb the effects of aging.

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Other signs of aging such as skin sagging and volume loss are also meant to be reversed by the application of progeline cream to the skin. Instead, progeline has only been proven to smooth out fine lines on the skin as several moisturizers can easily do.

The Lucas Meyer Cosmetics Company states that the progeline cream is to serve the purpose of reducing progerin synthesis, inhibiting MMPs and Elatase, increasing syndecan, and contracts collagen. These are meant to slow down the aging process of the human body.

2. Progeline Is Known To Hydrate The Skin

One application of the progeline cream is sure to remarkably hydrate a person’s skin. Owing to the presence of glycerin and water in progeline cream the body is sure to get hydrated when it is used on the skin.

Glycerin is excellent for hydrating the skin because it draws moisture from the inner layer of the skin up to the epidermis to give the skin a healthy glow. It is the presence of glycerin that ensures the disappearance of fine lines on the skin when progeline cream is used.

Asides from skin hydration, the glycerin present in progeline cream makes for a soft and supple feel to the skin, and this is also why progeline cream is often likened to a moisturizer.

Progeline Cream: Usage, Benefits, Side Effects, FAQs | AllBodyYoga (2)

What Are The Disadvantages Of Using Progeline Cream?

Progeline creams are still being researched by dermatologists and other doctors in related medical fields. This ongoing research may discourage persons to purchase the progeline cream because the long-term effects have not yet been determined.

It is however safe to say that progeline creams do not possess any ingredients that could cause harm to your skin. It is safe to purchase a progeline cream if you want to have an unbiased opinion on its originality based on the functions the Lucas Meyer Cosmetics Company outlines.

Purchasing a progeline cream that costs a lot of money while you are unsure it performs the functions it is said to, would only be a disadvantage when it does not turn out to indeed function as an anti-aging cream. If this is the case, you would have wasted good money being a means for research.

What Other Ingredients Help With Anti-Aging?

Since progeline has been proven as an unreliable treatment for anti-aging, below are some alternative ingredients in creams that firm the skin and eliminate wrinkles;

1. Retinoids

Retinoids are Vitamin A compounds such as retinol and retinoic acid. These particular ingredients have been instrumental in repairing skin damaged by the sun and reducing the appearance of fine lines and wrinkles on the skin.

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2. Hydroxy Acid

Hydroxy Acids are a great anti-aging ingredient because of their ability to reduce dead skin, it is used to prepare and open up the skin to absorb other products properly. It also helps encourage the growth of smooth and even skin tone. These Alpha Hydroxy Acids include glycolic, citric, and lactic acids.

3. Vitamin C/Ascorbic Acid

Vitamin C in skin products are made use of because of their anti-oxidant qualities, this means it protects the skin from unstable oxygen molecules that destroy skin cells and result in wrinkles on the body. Vitamin C also protects the skin from sun damage as well as reduces fine lines and wrinkles on the skin.

Progeline Cream: Usage, Benefits, Side Effects, FAQs | AllBodyYoga (3)

4. Niacinamide

A Niacinamide is an ingredient closely associated with Vitamin B-3 or Niacin, it also works as an antioxidant to decrease water loss in the skin and in some instances may boost skin elasticity to improve the overall appearance of the skin.

5. Tea Extracts

There are several skin DIY processes that are centered on using tea extracts to firm the skin. Apparently, green, black, and oolong tea possess solvents with anti-oxidant and anti-inflammatory abilities. With these present in a cream, it is likely to help in the prevention of wrinkles and fine lines.

Does Progeline Cream Really Work?

Unfortunately, there are not sufficient clinical data or research findings to prove that the functions mentioned by the company that produces progeline cream are indeed true. Within the short term of usage, people have complained and concluded that progeline creams do not work.

Progeline creams contain a higher concentration of dextran, glycerol, and water and a lesser concentration of peptide which should serve as the main ingredient for increasing the production of collagen in the body in order to fight the aging process in the human body.

The small amounts of peptide found in the progeline cream are gotten rid of by your body instead of absorbed to boost the release of collagen in your body. A progeline cream may only serve as a hydrating or moisturizing agent for the skin, not as an anti-aging product.

Progeline Creams Frequently Asked Questions

What Are The Ingredients In Progeline Cream?

The Progeline Cream contains four major ingredients which are water, glycerin, dextran, and a fluorinated peptide known as triflrifluoroacetyl tripeptide 2.

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What Is Progerine Cream?

A Progerin cream is a bioengineered peptide formula gotten from Elafin for the skin by the Lucas Meyer Cosmetic Company, it is meant to be an effective cream that prevents saggy skin, the appearance of wrinkles hydrates the skin, and gives it volume. It is simply an anti-aging cream made from a mixture of water, glycerin, dextran, and triflrifluoroacetyl tripeptide 2.

Do Peptide Creams Really Work?

The studies that identify peptides as a means of collagen production to slow down the aging process make it seem like an effective treatment for wrinkles, saggy, dull, and dehydrated skin. Peptide creams have not been completely proven to correct the changes that accompany the big process but when applied religiously they are said to provide healthier skin.

How Long Does It Take For Peptides To Work?

Peptides can offer visible results within the first few weeks of being used, but to uncover their full potential or benefits, it would require a constant application for about three to six months for the peptides.


With the interest shown in skincare and beauty routines, it is no wonder that a cream such as progeline has so many unanswered questions. As an anti-aging cream progeline boasts of the ability to firm saggy skin, prevent wrinkles as a person ages, reduce the synthesis of progerin, and reduce volume loss.

These claims sound good and promising to a lot of people, the aging process is not particularly fun, and several persons would rather opt for a cream such as this instead of the surgeries that are commonly used to firm the skin and eliminate wrinkles.

Using a cream to slow down the again process sounds safer than undergoing surgical procedures so naturally, the thought of cream such as progeline would seem more appealing. However, judging from what is mentioned above based on the cream, it is still being researched and tested out to make certain that the mentioned benefits are achievable by applying the cream.

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Judging from research that had been done, the progeline cream does not perform anti-aging functions. Instead, it acts as a moisturizer would by hydrating the skin and eliminating fine lines.

This would make one question the authenticity of peptides that are present in progeline cream, the simple explanation that suffices is that the concentration of peptides in the progeline cream is rather low in comparison to other ingredients.

The peptides ought to be the major ingredient because of their protein concentration that allows them to boost collagen production and in turn reverse the changes experienced during the aging process.

  1. Jenny Jin ( April, 2021 ), What Is Progeline Cream And Does It Really Work?
  2. Dr Hannah Sivak ( January 2020 ), What On Earth Is Progeline?
  3. Brooke Shunatona ( September 2021 ), Progeline Cream: Benefits And How To Use
  4. Future Derm ( December 2015 ), Do Peptides Really Work Or Not?
  5. Miami MD ( January 2021 ), What Is Progeline, And Why Is It Beneficial In Skin Care?
  6. Gundry MD ( January 2017 ), The Anti Aging Powers Of Progeline ( + How It Helps Fight Wrinkles! )
  7. Mayo Clinic ( 2020 ), Wrinkle Creams: Your Guide To Younger Skin


How do you reduce progerin in your skin? ›

The buildup of progerin, an abnormal protein, interferes with normal cell functions and can cause early cellular aging. A substance in broccoli called sulforaphane can help break down progerin.

What does progeline do to your skin? ›

When progeline is used in skincare products, it can send necessary signals to your body to reduce signs of aging. This includes preventing saggy skin, minimizing wrinkles' appearance, and making our skin more hydrated and firm.

What are the benefits of progeline? ›

What are the benefits of progeline cream? “The company [who produces the ingredient] claims that progeline cream reduces synthesis of progerin, inhibits MMPs, contracts collagen and increases syndecan—all of which basically translates to decreased wrinkling, skin sagging and volume loss,” explains Hartman.

What are the side effects of anti-aging cream? ›

You'll likely need to use the wrinkle cream once or twice a day for many weeks before noticing any improvement. And once you discontinue using the product, your skin is likely to return to its original appearance. Side effects. Some products may cause skin irritation, rashes, burning or redness.

What causes high levels of progerin? ›

A single gene mutation is responsible for progeria. The gene, known as lamin A (LMNA), makes a protein necessary for holding the center (nucleus) of a cell together. When this gene has a defect (mutation), an abnormal form of the lamin A protein called progerin is produced and makes cells unstable.

Can sagging skin reversed? ›

Of course, you can't reverse the signs of aging completely. You can go the nonsurgical route and add firming creams or facial exercises to your skincare routine. There are also cosmetic procedures that provide quicker results, such as laser surfacing or ultrasound skin tightening.

Does progerin cause aging? ›

Hutchinson-Gilford progeria syndrome is a genetic disease which is inherited dominantly. Symptoms of the disease appear in the first months of life and they include accelerated aging, delayed growth, loss of subcutaneous fat, baldness, decreased density of bone, and weak muscles.

How long does anti-aging cream take to work? ›

Anti-aging products

Anti-aging skincare products can take as little as two weeks and as much as three months to show noticeable results. It's commonly known that the more consistent you are in using the products, the more beneficial results they will yield.

What are the side effects of collagen cream on face? ›

Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Can taking collagen reverse sagging skin? ›

Does Collagen Tighten Saggy Skin? Studies have indicated that supplemental collagen is beneficial for skin health, including tightening sagging skin (known as elasticity), boosting hydration, and lessening the appearance of wrinkles.

Can taking collagen reverse wrinkles? ›

Current research reveals that collagen use could result in a reduction of wrinkles, rejuvenation of skin, and reversal of skin aging [16], which may improve skin hydration and elasticity [17].

Does taking collagen make your skin look younger? ›

"Collagen is what keeps our skin from sagging, giving us that plump, youthful look," says dermatologist Dr. Ohara Aivaz.

What happens if you use anti-aging products too early? ›

"Some skin care products claim to increase cell turnover or to repair collagen breakdown," Zeichner says. "In your 20s, you have excellent turnover without any help, and your skin is fully capable of repairing itself. The downside is that these products may irritate your skin or make it more sensitive to the sun."

What is the best treatment for deep wrinkles on face? ›

Soft tissue fillers, which include fat, collagen and hyaluronic acid (Restylane, Juvederm, others), can be injected into wrinkles on your face. They plump and smooth wrinkles and furrows.

How can I make my face look younger naturally? ›

11 ways to reduce premature skin aging
  1. Protect your skin from the sun every day. ...
  2. Apply self-tanner rather than get a tan. ...
  3. If you smoke, stop. ...
  4. Avoid repetitive facial expressions. ...
  5. Eat a healthy, well-balanced diet. ...
  6. Drink less alcohol. ...
  7. Exercise most days of the week. ...
  8. Cleanse your skin gently.
Feb 24, 2021

Where does progerin accumulate? ›

Progerin accumulates at the inner nuclear lamina and disrupts its properties causing the characteristic nuclear blebbing and a variety of cellular defects, including epigenetic modifications, senescence, and DNA repair deficiency (Kubben and Misteli, 2017).

Why is progerin bad? ›

Both mice and humans with progeria show many signs of aging, including DNA damage, cardiac dysfunction and dramatically shortened life span.

What foods slow down aging? ›

Foods to Favor
  • Romaine lettuce. It's high in vitamins A and C, which curb inflammation. ...
  • Tomatoes. They're rich in a nutrient called lycopene. ...
  • Salmon. It's high in omega-3 fats, which fight inflammation. ...
  • Lentils and beans. These are good sources of protein and are loaded with fiber and nutrients. ...
  • Oatmeal.
Sep 22, 2014

What vitamins make skin tighter? ›

Vitamins A, C and E

Vitamin A helps to hydrate the lower layer of skin, vitamin C preserves and protects skin-firming fibers such as collagen and elastin, and vitamin E safeguards skin from sun damage. To employ this powerful protection for your skin, eat more leafy greens and colorful fruits and vegetables.

How can a 70 year old woman look younger? ›

Practice Good Self-Care to Prevent Aging Skin

In addition to sleeping on Blissy silk pillowcases, taking good care of your health can help you look and feel younger as you age. This involves eating nutritious foods, exercising regularly, drinking plenty of water, and making sure to get enough sleep.

What vitamin deficiency causes sagging skin? ›

How vitamin D deficiency leads to accelerated skin aging isn't fully understood. However, some experts suspect it has something to do with vitamin D's protective and antioxidant properties on the skin.

Does vitamin D reduce progerin? ›

The finding that vitamin D reduces progerin levels is of high significance (Figure ​ 5). Studies have shown a decrease in progerin protein levels by treatment with rapamycin or sulforaphane, by activating its clearance via autophagy [47, 48].

Can rapid aging be reversed? ›

A note from Cleveland Clinic

You can protect or reverse premature aging: Protect your skin from sun exposure, quit smoking, eat a well-balanced diet and exercise.

What causes rapid face aging? ›

Ultraviolet radiation, which speeds the natural aging process, is the primary cause of early wrinkling. Exposure to UV light breaks down your skin's connective tissue — collagen and elastin fibers, which lie in the deeper layer of skin (dermis).

What time of day should I use anti-aging cream? ›

When to Apply. Typically, anti-aging creams should be applied twice a day – first thing in the morning and the last thing in the evening before bed. If you want to maximise the effect of an anti-wrinkle cream, you must give the product enough time to be absorbed into your skin before applying any other products.

How long should you use a product to see results? ›

On average, it takes four to six weeks to see any real difference from the skin care products that you've just started using.

Can you put tretinoin under eyes? ›

Do not use this medicine in or around the eyes or lips, or inside of the nose. Spread the medicine away from these areas when applying. If it accidentally gets on these areas, wash with water at once. Before applying tretinoin, wash the skin with a mild soap or cleanser and warm water by using the tips of your fingers.

What are symptoms of too much collagen? ›

Collagen is a protein that makes up connective tissues, such as the skin. When you have too much collagen, your skin can stretch, thicken, and harden. It also can cause damage to internal organs, such as the heart, lungs, and kidneys.

Does collagen have side effects on kidneys? ›

It contains hydroxyproline, a type of amino acid that's converted into oxalate in your body, which may increase urinary oxalate excretion. For those prone to developing kidney stones, it may be better to avoid consuming high amounts of collagen from foods or supplements.

What tightens loose skin? ›

Loose skin can be tightened with collagen supplements, bariatric surgery, or radiofrequency treatments.

How can I rebuild collagen in my face? ›

Ways to boost collagen
  1. Collagen supplements. People take collagen supplements for their joint and skin health. ...
  2. Hyaluronic acid. Hyaluronic acid is a compound that helps promote collagen production. ...
  3. Vitamin C. ...
  4. Aloe vera gel. ...
  5. Ginseng. ...
  6. Antioxidants. ...
  7. Retinol and other carotenoids. ...
  8. Light therapy.

Should a 60 year old woman take collagen? ›

Studies have shown that supplementing with collagen peptides — broken down collagen that's easier for your body to absorb — may be beneficial for older people and promote skin and bone health during aging.

How long does it take to rebuild collagen in face? ›

Initial results from collagen restoration treatments are usually visible immediately. However, new collagen growth can take anywhere from four to 12 weeks to complete.

What foods are high in collagen? ›

So, with that said, here are the 10 best collagen-rich foods to add to your eating pattern to boost your intake.
  • Beef Bone Broth. Bovine—aka cattle—is one of the top sources of collagen on the market. ...
  • Pork Bone Broth. ...
  • Sardines. ...
  • Organ Meats. ...
  • Collagen-Infused Drinks. ...
  • Gummy Candy. ...
  • Berries. ...
  • Broccoli.
May 9, 2022

Which vitamin makes you look younger? ›

Whether you want to reduce fine lines and wrinkles, have more moisturized skin, or clear up redness, the best vitamins to meet your needs include vitamins E, C, A, D, B, and K.

Will collagen help Crepey skin? ›

To ease crepey skin from within, you should ingest collagen from food sources. "Collagen-rich foods can significantly support skin hydration and elasticity," board-certified family physician and functional medicine expert Alejandra Carrasco, M.D., once told mbg.

Does collagen reduce belly fat? ›

Collagen does not help with body fat because you cannot reduce fat in specific areas of your body. You can lose weight using collagen rich foods like bone broth, but it will not specifically target your belly fat. Nothing will.

What protein tightens Crepey skin? ›

The formation of AGEs is another culprit of skin aging. So the more sugar you eat, the more AGEs your body produces. As just mentioned, collagen the protein that keeps your skin firm and elastic is the most abundant protein in your body.

What is the 1 protein you need for Crepey skin? ›

Salmon is the one protein you should be eating if you have sagging skin. That's because the fish is filled with nutrients beneficial for skin health like omega-3 fatty acids, B-12 vitamins, and selenium.

How can I reverse the signs of aging on my face? ›

11 ways to reduce premature skin aging
  1. Protect your skin from the sun every day. ...
  2. Apply self-tanner rather than get a tan. ...
  3. If you smoke, stop. ...
  4. Avoid repetitive facial expressions. ...
  5. Eat a healthy, well-balanced diet. ...
  6. Drink less alcohol. ...
  7. Exercise most days of the week. ...
  8. Cleanse your skin gently.
Feb 24, 2021

What vitamin is lacking for Crepey skin? ›

To try and reduce the chances of developing crepey skin, it is essential to include the following in a balanced diet:
  • antioxidants such as carotenoids, tocophenols, and flavonoids.
  • vitamins A, C, D, and E.
  • omega-3 fatty acids.

What plumps Crepey skin? ›

Hyaluronic acid will help plump and hydrate skin which improves the immediate appearance of crepey skin. The addition of antioxidants such as Vitamin C, E have the effect of reducing oxidative stress and damage to skin and can stimulate new collagen growth.

What food has highest collagen? ›

The following three foods contain high levels of collagen:
  1. Bone Broth. Bone broth is made by simmering animal bones and connective tissue for an extended period of time. ...
  2. Fish With the Skin On. Fish are an excellent source of collagen from food, as long as you leave the skin on. ...
  3. Chicken.
Dec 7, 2022

Does tapping face stimulate collagen? ›

Just five minutes a day of regular tapping:

plumps the face and smoothes wrinkles by stimulating collagen production; normalizes the activity of oil and sweat glands.

Does drinking collagen help Crepey skin? ›

A: Collagen supplements aren't the best option if you want to improve the appearance of your skin. That's mainly because there's no evidence-based science to prove they work ― or that they're safe. A few small studies have shown limited improvement in skin texture with collagen supplements.

Does drinking water help with Crepey skin? ›

Drinking adequate amounts of water is important to keeping skin hydrated and supple, and is especially important in preventing crepey skin. By ensuring you are properly hydrated with a higher water intake, you can provide your skin with the hydration it requires to stay elastic and moisturized.

Does Vaseline help Crepey skin? ›

According to Zeichner, loss of hydration and the resulting inflammation worsens crepey skin. He recommends looking for purified petrolatum in your moisturizer, as in Vaseline's popular lotion. It protects the skin's barrier, prevents water loss, hydrates and plumps thin skin.

What makes a woman look younger? ›

Drinking enough water each day replenishes your skin's tissue and cells, allowing for younger and healthier looking skin. Another key to maintaining a youthful appearance is to simply get some rest! When you sleep, your body continuously releases hormones that promote cell turnover and renewal.

What is the best treatment for 70 year old skin? ›

Wash with a gentle, fragrance-free, moisturizing bar soap, cleanser, or body wash. Doing so will help soothe rather than dry your skin. Moisturizing ingredients that can help reduce dryness include glycerin, hyaluronic acid, and lanolin. Use warm (not hot) water.


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